After a single intravenous alendronate approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no excreted in the feces. Alendroiata Renal clearance was 71 ml / min, and systemic clearance did not exceed 200 ml / min. The plasma concentrations decreased by more than 95% within six hours after intravenous administration.
The half-life in the terminal phase in humans is estimated to exceed ten years, reflecting release of alendronate from the skeleton. Alendronate is not output through the acidic and basic transport system of kidneys in rats; thus it can be expected that it does not disturb the removal of other drugs through these systems in humans.